Post-traumatic stress disorder, often abbreviated as PTSD, is a complex disorder in which the affected person's memory, emotional responses, intellectual processes, and nervous system have all been disrupted by one or more traumatic experiences. It is sometimes summarized as "a normal reaction to abnormal events." The DSM-IV-TR(the professional's diagnostic manual) classifies PSTD as an anxiety disorder.
PTSD has a unique position as the only psychiatric diagnosis(along with acute stress disorder) that depends on a factor outside the individual, namely, a traumatic stressor. A patient cannot be given a diagnosis of PTSD unless he or she has been exposed to an event that is considered traumatic. These events include such obvious traumas as rape, military combat, torture, genocide, natural disasters, and transportation or workplace disasters. In addition, it is now recognized that repeated traumas or such traumas of long duration as child abuse, domestic violence, stalking, cult membership, and hostage situations may also produce the symptoms of PTSD in survivors.
A person suffering from PTSD experiences flashbacks, nightmares, or daydreams in which the traumatic event is experienced again. The person may also experience abnormally intense startle responses, insomnia, and may have difficulty concentrating. Trauma survivors with PTSD have been effectively treated with group therapy or individual psychological therapy, and other therapies have helped individuals, as well. Some affected individuals have found support groups or peer counseling groups helpful. Treatment may require several years, and in some cases, PTSD may affect a person for the rest of his or her life.
PTSD is much more widespread in the general population than was thought when it was first introduced as a diagnostic category. The National Comorbidity Survey, a major epidemiological study conducted between 1990 and 1992, estimates that the lifetime prevalence among adult Americans is 7.8%, with women (10.4%) twice as likely as men (5%) to be diagnosed with PTSD at some point in their lives. These figures represent only a small proportion of adults who have experienced at least one traumatic event—60.7% of men and 51.2% of women respectively. More than 10% of the men and 6% of the women reported experiencing four or more types of trauma in their lives. The most frequently mentioned traumas are:
The traumatic events most frequently mentioned by men diagnosed with PTSD are rape, combat exposure, childhood neglect, and childhood physical abuse. For women diagnosed with PTSD, the most common traumas are rape, sexual molestation, physical attack, being threatened with a weapon, and childhood physical abuse.
Some subpopulations in the United States are at greater risk of developing PTSD. The lifetime prevalence of PTSD among persons living in depressed urban areas or on Native American reservations is estimated at 23%. For victims of violent crimes, the estimated rate is 58%.
Information about PTSD in veterans of the Vietnam era is derived from the National Vietnam Veterans Readjustment Survey (NVVRS), conducted between 1986 and 1988. The estimated lifetime prevalence of PTSD among American veterans of this war is 30.9% for men and 26.9% for women. An additional 22.5% of the men and 21.2% of the women have been diagnosed with partial PTSD at some point in their lives. The lifetime prevalence of PTSD among veterans of World War II and the Korean War is estimated at 20%.
Further research needs to be done on the effects of ethnicity and culture on post-traumatic symptoms. As of 2001, most PTSD research has been done by Western clinicians working with patients from a similar background. Researchers do not yet know whether persons from non-Western societies have the same psychological reactions to specific traumas or whether they develop the same symptom patterns.
When PTSD was first suggested as a diagnostic category for DSM-IIIin 1980, it was controversial precisely because of the central role of outside stressors as causes of the disorder. Psychiatry has generally emphasized the internal weaknesses or deficiencies of individuals as the source of mental disorders; prior to the 1970s, war veterans, rape victims, and other trauma survivors were often blamed for their symptoms and regarded as cowards, moral weaklings, or masochists. The high rate of psychiatric casualties among Vietnam veterans, however, led to studies conducted by the Veterans Administration. These studies helped to establish PTSD as a legitimate diagnostic entity with a complex set of causes.
BIOCHEMICAL/PHYSIOLOGICAL CAUSES. Present neurobiological research indicates that traumatic events cause lasting changes in the human nervous system, including abnormal secretions of stress hormones. In addition, in PTSD patients, researchers have found changes in the amygdala and the hippocampus—the parts of the brain that form links between fear and memory. Experiments with ketamine, a drug that inactivates one of the neurotransmitter chemicals in the central nervous system, suggest that trauma works in a similar way to damage associative pathways in the brain. Positron emission tomography(PET) scans of PTSD patients suggest that trauma affects the parts of the brain that govern speech and language.
SOCIOCULTURAL CAUSES. Studies of specific populations of PTSD patients (combat veterans, survivors of rape or genocide, former political hostages or prisoners, etc.) have shed light on the social and cultural causes of PTSD. In general, societies that are highly authoritarian, glorify violence, or sexualize violence have high rates of PTSD even among civilians.
OCCUPATIONAL FACTORS. Persons whose work exposes them to traumatic events or who treat trauma survivors may develop secondary PTSD (also known as compassion fatigue or burnout). These occupations include specialists in emergency medicine, police officers, firefighters, search-and-rescue personnel, psychotherapists, disaster investigators, etc. The degree of risk for PTSD is related to three factors: the amount and intensity of exposure to the suffering of trauma victims; the worker's degree of empathy and sensitivity; and unresolved issues from the worker's personal history.
PERSONAL VARIABLES. Although the most important causal factor in PTSD is the traumatic event itself, individuals differ in the intensity of their cognitive and emotional responses to trauma; some persons appear to be more vulnerable than others. In some cases, this greater vulnerability is related to temperament or natural disposition, with shy or introverted people being at greater risk. In other cases, the person's vulnerability results from chronic illness, a physical disability, or previous traumatization—particularly abuse in childhood. As of 2001, researchers have not found any correlation between race and biological vulnerability to PTSD.
DSM-IV-TRspecifies six diagnostic criteria for PTSD:
The diagnosis of PTSD is complicated by several factors.
In the case of a known trauma of recent occurrence—most often a civilian disaster or war—the diagnosis of PTSD is relatively straightforward, based on the criteria listed above.
DSM-IVintroduced a new diagnostic category, acute stress disorder, to differentiate between time-limited and longer-term stress reactions. In acute stress disorder, the hyperarousal and intrusive symptoms last between two days and four weeks. If the symptoms last beyond four weeks, and all of the above criteria are met, the diagnosis is changed to PTSD.
The diagnosis of PTSD is more difficult in cases of delayed reaction to trauma. Some individuals do not develop symptoms of PTSD until months or even years after the traumatic event. DSM-IV-TRspecifies an interval of at least six months between the event and the development of symptoms for a diagnosis of PTSD with delayed onset. Delayed symptoms are often triggered by a situation that resembles the original trauma, as when a person raped in childhood experiences workplace sexual harassment.
DSM-IIIand its successors included the category of adjustment disorder to differentiate abnormal reactions to such painful but relatively common life events ("ordinary stressors") as divorce, job loss, or bereavement from symptoms resulting from overwhelming trauma. The differential diagnosis (the process of determining that the diagnosis is one disorder although it may resemble another) is complicated, however, by the fact that "ordinary stressors" sometimes reawaken unresolved childhood trauma, producing the delayed-reaction variant of PTSD.
Most patients with PTSD (as many as 80%) have been diagnosed with one of the anxiety (30–60%), dissociative, mood (26–85%), or somatoform disorders as well as with PTSD. Between 40–60% of persons with delayed-reaction PTSD are diagnosed with a personality disorder, most often borderline personality disorder. Another common dual diagnosis is PTSD/substance abuse disorder. Between 60%–80% of patients who develop PTSD turn to alcohol or narcotics in order to avoid or numb painful memories. According to the NVVRS, the estimated lifetime prevalence of alcohol abuse among male Vietnam veterans is 39.2%, and the estimated lifetime prevalence of drug abuse is 5.7%. Dual diagnoses complicate treatment because the therapist

As of 2002, there are no physical tests to establish a diagnosis of PTSD. The diagnosis is usually made on the basis of the patient's history and results from one or more short-answer interviews or symptom inventories. The instruments most often used to evaluate patients for PTSD include the Anxiety Disorders Interview Scale (ADIS), the Beck Depression Inventory, the Clinician-Administered PTSD Scale (CAPS), the Disorders of Extreme Stress Inventory (DESI), the Dissociative Experiences Scale (DES), the Hamilton Anxiety Scale, and the Impact of Event Scale (IES).
In general, there have been few well-controlled clinical trials of treatment options for PTSD, particularly for severely affected patients.
Critical incident stress debriefing (CISD) is a treatment offered to patients within 48 hours following a civilian disaster or war zone trauma. It is intended to weaken the acute symptoms of the trauma and to forestall the development of full-blown PTSD. CISD usually consists of four phases:
Critical incident stress management is a system of interventions designed to help emergency/disaster response workers, public safety personnel, and therapists deal with stress reactions before they develop secondary PTSD.
Other mainstream treatment methods used with patients who have already developed PTSD include:
In general, medications are used most often in patients with severe PTSD to treat the intrusive symptoms of the disorder as well as feelings of anxiety and depression. These drugs are usually given as one part of a treatment plan that includes psychotherapy or group therapy. As of 2002, there is no single medication that appears to be a "magic bullet" for PTSD. The selective serotonin reuptake inhibitors (SSRIs) appear to help the core symptoms when given in higher doses for five to eight weeks, while the tricyclic antidepressants (TCAs) or the monoamine oxidase inhibitors (MAOIs) are most useful in treating anxiety and depression.
Some alternative therapies for PTSD include:
Since the mid-1980s, several controversial methods of treatment for PTSD have been introduced. Some have been developed by mainstream medical researchers while others are derived from various forms of alternative medicine. They include:
Trauma survivors who receive critical incident stress debriefing as soon as possible after the event have the best prognosis for full recovery. For patients who develop full-blown PTSD, a combination of peer-group meetings and individual psychotherapy are often effective. Treatment may require several years, however, and the patient is likely to experience relapses.
There are no studies of untreated PTSD, but long-term studies of patients with delayed-reaction PTSD or delayed diagnosis of the disorder indicate that treatment of patients in these groups is much more difficult and complicated.
In some patients, PTSD becomes a chronic mental disorder that can persist for decades, or the remainder of the patient's life. Patients with chronic PTSD often have a cyclical history of symptom remissions and relapses. This group has the poorest prognosis for recovery; some patients do not respond to any of the currently available treatments for PTSD.
Some forms of trauma, such as natural disasters and accidents, can never be completely eliminated from human life. Traumas caused by human intention would require major social changes to reduce their frequency and severity, but given the increasing prevalence of PTSD around the world, these long-term changes are worth the effort. In the short term, educating people—particularly those in the helping professions—about the signs of critical incident stress may prevent some cases of exposure to trauma from developing into full-blown PTSD.
See also Anxiety reduction techniques; Bodywork therapies; Creative therapies; Exposure treatment; Somatization and Somatoform disorders
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders.4th edition, text revised. Washington, DC: American Psychiatric Association,2000.
Beers, Mark H., M.D., and Robert Berkow, M.D., eds. "Posttraumatic Stress Disorder." In The Merck Manual of Diagnosis and Therapy,17th edition. Whitehouse Station, NJ: Merck Research Laboratories, 1999.
Herman, Judith, M.D. Trauma and Recovery.2nd ed., revised. New York: Basic Books, 1997.
Laub, Dori, M.D. "An Event Without A Witness: Truth, Testimony and Survival." In Testimony: Crises of Witnessing in Literature, Psychoanalysis, and History, written by Dori Laub, M.D. and Shoshana Felman. New York: Routledge, 1992.
American Psychiatric Association. 1400 K Street NW, Washington D.C. 20005. <http://www.psych.org>.
Anxiety Disorders Association of America, Inc. 11900 Parklawn Drive, Suite 100, Rockville, MD 20852. (301) 231-9350. <http://www.adaa.org>.
International Critical Incident Stress Foundation, Inc. 10176 Baltimore National Pike, Unit 201, Ellicott City, MD21042. (410) 750-9600. Emergency: (410) 313-2473. <http://www.icisf.org>.
International Society for Traumatic Stress Studies. 60 Revere Drive, Suite 500, Northbrook, IL 60062. (847) 480-9028. <http://www.istss.org>.
National Center for PTSD. 1116D V.A. Medical Center, 215 N. Main Street, White River Junction, VT 05009-0001.(802) 296-5132. <http://www.ncptsd.org>.
National Institute of Mental Health. 6001 Executive Boulevard, Rm. 8184, MSC 9663, Bethesda, MD 20892-9663. (301) 443-4513. <http://www.nimh.nih.gov>.
Rebecca J. Frey, Ph.D.
The following comments are not guaranteed to be that of a trained medical professional. Please consult your physician for advice.

