Narcolepsy 1079
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Narcolepsy is a disorder marked by excessive daytime sleepiness, uncontrollable sleep attacks, and cataplexy (a sudden loss of muscle tone, usually lasting up to half an hour).


Narcolepsy is the second-leading cause of excessive daytime sleepiness (after obstructive sleep apnea). Persistent sleepiness and sleep attacks are the hallmarks of this condition. The sleepiness has been compared to the feeling of trying to stay awake after not sleeping for two or three days.

People with narcolepsy fall asleep suddenly—anywhere, at any time, even in the middle of a conversation. These sleep attacks can last from a few seconds to more than an hour. Depending on where the sleep attacks occur, they may be mildly inconvenient or even dangerous to the person, particularly if they occur while he or she is driving. Some people continue to function outwardly during the sleep episodes, such as continuing a conversation or putting things away. But when they wake up, they have no memory of the event.

Sleep researchers have identified several different types of sleep in humans. One type of sleep is called rapid eye movement (REM) sleep, because the person's eyes move rapidly back and forth underneath the closed eyelids. REM sleep is associated with dreaming. Normally, when people fall asleep, they experience 90 minutes of non-REM sleep, which is then followed by a phase of REM sleep. People with narcolepsy, however, enter REM sleep immediately. In addition, REM sleep occurs inappropriately in patients with narcolepsy throughout the day.

Causes and symptoms


One of the causes of narcolepsy is a genetic mutation. In 1999 researchers identified the gene that causes the disorder. The narcolepsy gene allows cells in the hypothalamus (the part of the brain that regulates sleep behavior) to receive messages from other cells. As a result of the mutation, the cells cannot communicate properly, and abnormal sleeping patterns develop.

Other researchers are also looking into the possibility that narcolepsy may be caused by some kind of autoimmune disorder. This theory suggests that the person's immune system accidentally turns against the specific area of the brain that controls alertness and sleep, injuring or destroying it.

The disorder sometimes runs in families, but most people with narcolepsy have no relatives with the disorder. Researchers believe that the inheritance of narcolepsy is similar to that of heart disease. In heart disease, several genes play a role in being susceptible to the disorder, but it does not usually develop without an environmental trigger of some sort.


While the symptoms of narcolepsy usually appear during a person's late teens or early 20s, the disease may not be diagnosed for many years. Most often, the first symptom is an overwhelming feeling of fatigue . After several months or years, cataplexy and other symptoms of the disorder appear.

Cataplexy is the most dramatic symptom of narcolepsy, affecting 75% of people with the disorder. During attacks, the knees buckle and the neck muscles go slack. In extreme cases, the person may become paralyzed and fall to the floor. This loss of muscle tone is temporary, lasting from a few seconds to half an hour, but it is frightening. The attacks can occur at any time but are often triggered by such strong emotions as anger, joy, or surprise.

Other symptoms of narcolepsy include:

  • sleep attacks: short, uncontrollable sleep episodes throughout the day
  • sleep paralysis: a frightening inability to move shortly after awakening or dozing off
  • auditory or visual hallucinations : intense, sometimes terrifying experiences at the beginning or end of a sleep period
  • disturbed nighttime sleep: tossing and turning, nightmares, and frequent awakenings during the night


There has been debate over the incidence of narcolepsy. It is thought to affect between one in every 1,000 to 2,000 Americans. The known prevalence in other countries varies, from one in 600 in Japan to one in 500,000 in Israel. The reasons for these demographic differences are not clear. In about 8–12% of cases, people diagnosed with narcolepsy know of other family members with similar symptoms.


The diagnosis of narcolepsy can be made by a general practitioner familiar with the disorder as well as by a psychiatrist . If a person comes to the doctor with reports of both excessive daytime sleepiness and cataplexy, a diagnosis may be made on the patient's history alone. Laboratory tests, however, can confirm a diagnosis of narcolepsy. These tests may include an overnight polysomnogram— a test in which sleep is monitored with a variety of electrodes that record information about heart rate, eye movements, brain waves, muscle activity, breathing, changes in blood oxygen concentration, and body position. A Multiple Sleep Latency Test, which measures sleep latency (onset) and how quickly REM sleep occurs, may also be used. People who have narcolepsy usually fall asleep in less than five minutes.

If the diagnosis is still open to question, a genetic blood test can reveal the existence of certain substances in people who have a tendency to develop narcolepsy. Positive test results suggest, but do not prove, that the patient has narcolepsy.

Narcolepsy is a complex disorder, and it is often misdiagnosed. Many people with the disorder struggle with symptoms for an average of 14 years before being correctly diagnosed.


There is no cure for narcolepsy. It is not progressive, and it is not fatal, but it is a chronic disorder. The symptoms can be managed with lifestyle adjustments and/or medication.

People with narcolepsy must plan their days carefully. Scheduling regular naps (either several short, fifteen-minute naps or one long nap in the afternoon) can help boost alertness and awakeness. A full eight hours of nighttime sleep should also be a goal. Exercise can often help people with narcolepsy feel more alert and energetic, although they should avoid exercising within a few hours of bedtime. Substances that contain alcohol, nicotine, and caffeine should be avoided because they can interfere with refreshing sleep and with daytime alertness.

Medications for narcolepsy may include the use of antidepressants (tricyclic antidepressants or selective serotonin-reuptake inhibitors) to treat such symptoms of the disorder as cataplexy, hypnagogic hallucinations, and/or sleep paralysis.

Stimulants ( amphetamines ) may also be used to help individuals with narcolepsy stay awake and alert.

With the recent discovery of the gene that causes narcolepsy, researchers are hopeful that other treatments can be designed to relieve the symptoms of the disorder.


Narcolepsy is not a degenerative disease, and patients do not develop other neurologic symptoms. Narcolepsy can, however, interfere with a person's ability to work, play, drive, socialize, and perform other daily activities. In severe cases, the disorder prevents people from living a normal life, leading to depression and a loss of independence.


As of 2002, narcolepsy is not a preventable disorder.



Mignot, E. "Genetics of Narcolepsy and Other Sleep Disorders." American Journal of Human Genetics 60(1997): 1289-1302.

Siegel, Jeremy M. "Narcolepsy." Scientific American (January 2000). Available at: <> .


American Academy of Sleep Medicine. 6301 Bandel Rd. NW, Suite 101 Rochester, MN 55901. (507) 287-6008. .

American Sleep Disorders Association. 1610 14th St. NW, Suite 300, Rochester, MN 55901. (507) 287-6006.

Narcolepsy Network. PO Box 42460, Cincinnati, OH 45242. (973) 276- 0115.

National Center on Sleep Disorders Research. Two Rockledge Centre, 6701 Rockledge Dr., Bethesda, MD 20892. (301) 435-0199.

National Sleep Foundation. 1522 K St., NW, Suite 500, Washington, DC 20005. (202) 785-2300. <> .

Stanford Center for Narcolepsy. 1201 Welch Rd-Rm P-112, Stanford, CA 94305. (415) 725-6517.

University of Illinois Center for Narcolepsy Research. 845 S. Damen Ave., Chicago, IL 60612. (312) 996-5176.


"Stanford Researchers Nab Narcolepsy Gene For Sleep Disorders." Stanford University Medical Center . [August 5, 1999]. <> .

Rosalyn Carson-DeWitt, M.D.

Also read article about Narcolepsy from Wikipedia

User Contributions:

Why exactly are persons with narcolepsy so tired? Is going into REM quickly an unrestful sleep? And what about the person that drinks coffee all day once they finally get out of bed does that affect the quality of sleep that they receive?should they sleep 12 hours each night?

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