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SAD see Seasonal affective disorder

Sadism see Sexual sadism


SAMe (or S-adenosyl-L-methionine) is a naturally occurring chemical that is found throughout the entire body. It is involved in many chemical reactions that are necessary for life. SAMe is available as a natural dietary supplement that can be found at some pharmacies or health food stores, and can be purchased without a prescription.


People take supplements of SAMe for many reasons including its possible antidepressant effects. Some evidence suggests that taking SAMe can improve symptoms of depression within two weeks, which is considerably faster than the time it takes for oral antidepressant prescription drugs to work. (Prescription antidepressants often take a minimum of two weeks for patients to begin noticing any effect, and many take four to six weeks.)


SAMe is a specific form of the amino acid methionine, a substance that, when not metabolized properly, allows homocysteine to build up in the blood. SAMe is also an antioxidant, a substance that protects the body from damaging reactive oxygen molecules in the body. These reactive oxygen molecules can come from inside the body or from environmental pollution and are thought to play a role in the aging process and the development of degenerative disease. In general, SAMe is thought to raise the level of functioning of other amino acids in the body.

Although people use SAMe for many reasons including osteoarthritis, depression, heart disease, fibromyalgia, bursitis, tendonitis, chronic low back pain, dementia , Alzheimer's disease , improving brain function, multiple sclerosis, spinal cord injuries, migraine headaches, lead poisoning, liver disease, and to slow aging, the best evidence to date indicates that SAMe may be effective in relieving symptoms of osteoarthritis and for treating depression.

Several studies have indicated that oral SAMe and intravenous SAMe are effective treatments for depression. The studies researching the oral SAMe were small studies, and often were of short duration. However, the studies indicate that SAMe is effective in treating depression, and that it may be almost as effective as tricyclic antidepressants. Larger studies of SAMe are necessary.

Recommended dosage

SAMe can be taken orally or intravenously. Oral administration is more common. When taken by mouth, doses of 400–1,600 mg have been suggested. For osteoarthritis, 200–600 mg daily is a typical dose. For depression, 400–1,600 mg daily is a typical dose.

200 mg of SAMe have been administered intravenously or intramuscularly for 14 days while the patient simultaneously begins therapy with prescription antidepressant medication. If SAMe is used without prescription antidepressants, 200-400 mg per day by intravenous or intramuscular injections has been used. When treating other medical conditions, doses as high as 800 mg daily by injection have been used. Again, however, intravenous administration is rare in the United States.


As a natural supplement, SAMe has not been evaluated by the Food and Drug Administration. Claims of safety or effectiveness for treating any medical disorder have not been thoroughly studied by any governmental agency and there is no regulation of natural supplements. This means that potencies may vary between lots or among different manufacturers. It is also possible that supplements may not contain the ingredients that are listed on product labels.

SAMe should be used carefully by individuals with a history of bipolar disorder since it may aggravate symptoms of mania. When used with prescription antidepressant medications, life-threatening symptoms may occur. It should be used with prescription antidepressant drugs only under close medical supervision.

Side effects

When taken by mouth, SAMe may cause stomach upset including gas, vomiting, diarrhea, headache, and nausea. These symptoms are more common at high doses.

Anxiety has also occurred in people with depression, and mania has been reported in those with a history of bipolar disorder.


As stated, use of SAMe with antidepressants (especially selective serotonin reuptake inhibitors, or SSRIs) may cause life-threatening symptoms including agitation, tremors, anxiety, rapid heartbeats, difficulty breathing, diarrhea, shivering, muscle stiffness, and excessive sweating. The combination can also cause insomnia . If SAMe is used at the same time that prescription antidepressants are taken, close medical supervision is required.

SAMe may offer beneficial drug interactions when used with some medications. More research is necessary to determine whether SAMe does indeed protect the liver, but some scientists think that SAMe may protect the liver from damage caused by some drugs, including acetaminophen, alcohol, estrogens, steroids, and several other prescription drugs.

People interested in taking SAMe for depression should discuss its use with their doctor to weigh the potential benefits and risks.



Therapeutic Research Faculty. Natural Medicines Comprehensive Database. Stockton, CA: Natural Medicines Database, 2000.


Fetrow, C. W., Pharm.D. and J. R. Avila, Pharm.D. "Efficacy of the dietary supplement S-adenosyl-L-methionine." Annals of Pharmacotherapy 35, no. 11 (November 2001): 1414-1425.

Kelly Karpa, RPh, Ph.D.

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Also read article about SAMe from Wikipedia

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Feb 26, 2009 @ 10:10 am
I have been worried sick after taking a daily 200 mg of Sam - E for a few weeks. It relieved my hip pain however, I think it elevated my blood pressure from low/normal/ to high it is also making me feel a lot of strange symptoms like sever burning sensations in my left leg, gas, sleepiness, anxiety, mood swings, headaches, increase in appetite. I went to the doctor yesterday to have me checked for a heart attack and stroke, that's how bad and scared I felt. However, he did not find any reason for concern and I forgot to even tell him about the Sam-E because I thought it irrelevant. it was no until last night that I started thinking that maybe my problem was something new in my diet and realized I had introduced Sam-E. I still didn't think much of that but googled side effect and voila, there it was, most of it anyway. So I am wondering if there are people who have actually died because of Sam-E and thought it was somethings else. Yes, I know I said the word die, but that is how bad I felt. I am stopping taking it and will see how I fare.
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Sep 1, 2009 @ 2:14 pm
I started taking 400 mg SamE (Nature Made) 6 days ago. I don't have any side effects so far, and hoping that this will work. I was on Zoloft (50 mg) for 3 years and while on the first year taking it I lost 5 lbs, the second year I gained 10 lbs, and the last (3rd) year, I gained another 10 lbs. Since I'm small (original weight was 95-98 lbs), 5'0" with a small frame, the 20 lbs made me feel so heavy, and I was very depressed about it. So I don't want taking Zoloft anymore. So far I still don't feel the improvement to my moods (I had a 5 months break from gradually stopping Zoloft and taking SamE), but I am hopeful. I will update in a few weeks.

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